Table 1  Mutagenicity Testing Results
Chemical
 Type of Agent
 Relative Mutagenicity
Asbestos
unknown mechanism
++
Benzo(a)Pyrene
DNA adducts, requires S9
++
Chlorpheniramine maleate
False positive with MLA
-
Ethidium Bromide
DNA binding
+
Ethyl methane sulfonate (EMS)
Point mutagen
++++
Ethyl nitrosourea (ENU)
Point mutagen
++++
Gamma radiation
Clastogen
++++
Hydrogen peroxide
Oxidizing agent (ROS)
++
Lead acetate
Heavy metal
+++
MNNG
Point mutagen
++++
Mitomycin C
DNA cross-linking
+++
Sodium arsenite
Heavy metal, ROS
+++
Tetrachloroethane
False negative with MLA
+
Thalidomide
Negative control
-
UV radiation
Point mutagen
+++
Fig. 1  Sensitivity of Flow Cytometry Mutation Assay
(FCMA) vs MLA (gamma radiation)
Cytomation GTX, Inc.